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Helsen, Nicky; Vervoort, Tom; Vandenbossche, Joris; Lenz, Oliver; Monshouwer, Mario; Pauwels, Frederik; Snoeys, Jan

Effect of Plasma Protein Binding on the Anti-Hepatitis B Virus Activity and Pharmacokinetic Properties of NVR 3-778

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  • Media type: E-Article
  • Title: Effect of Plasma Protein Binding on the Anti-Hepatitis B Virus Activity and Pharmacokinetic Properties of NVR 3-778
  • Contributor: Helsen, Nicky; Vervoort, Tom; Vandenbossche, Joris; Lenz, Oliver; Monshouwer, Mario; Pauwels, Frederik; Snoeys, Jan
  • Published: American Society for Microbiology, 2018
  • Published in: Antimicrobial Agents and Chemotherapy, 62 (2018) 11
  • Language: English
  • DOI: 10.1128/aac.01497-18
  • ISSN: 1098-6596; 0066-4804
  • Keywords: Infectious Diseases ; Pharmacology (medical) ; Pharmacology
  • Origination:
  • Footnote:
  • Description: High plasma protein binding (PPB) levels not only affect drug-target engagement but can also impact exposure of hepatocytes to antivirals and thereby affect antiviral activity. In this study, we assessed the effect of PPB on the antiviral activity of NVR 3-778, a sulfamoylbenzamide capsid assembly modulator (CAM).
  • Access State: Open Access