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Walter, Kerstin; Kokesch-Himmelreich, Julia; Treu, Axel; Waldow, Franziska; Hillemann, Doris; Jakobs, Nikolas; Lemm, Ann-Kathrin; Schwudke, Dominik; Römpp, Andreas; Hölscher, Christoph

Interleukin-13-Overexpressing Mice Represent an Advanced Preclinical Model for Detecting the Distribution of Antimycobacterial Drugs within Centrally Necrotizing Granulomas

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  • Media type: E-Article
  • Title: Interleukin-13-Overexpressing Mice Represent an Advanced Preclinical Model for Detecting the Distribution of Antimycobacterial Drugs within Centrally Necrotizing Granulomas
  • Contributor: Walter, Kerstin; Kokesch-Himmelreich, Julia; Treu, Axel; Waldow, Franziska; Hillemann, Doris; Jakobs, Nikolas; Lemm, Ann-Kathrin; Schwudke, Dominik; Römpp, Andreas; Hölscher, Christoph
  • imprint: American Society for Microbiology, 2022
  • Published in: Antimicrobial Agents and Chemotherapy
  • Language: English
  • DOI: 10.1128/aac.01588-21
  • ISSN: 0066-4804; 1098-6596
  • Keywords: Infectious Diseases ; Pharmacology (medical) ; Pharmacology
  • Origination:
  • Footnote:
  • Description: <jats:p> The <jats:named-content content-type="genus-species">Mycobacterium tuberculosis</jats:named-content> -harboring granuloma with a necrotic center surrounded by a fibrous capsule is the hallmark of tuberculosis (TB). For a successful treatment, antibiotics need to penetrate these complex structures to reach their bacterial targets. </jats:p>
  • Access State: Open Access