WCK 5222 (Cefepime-Zidebactam) Pharmacodynamic Target Analysis against Metallo-β-Lactamase-Producing Enterobacteriaceae in the Neutropenic Mouse Pneumonia Model
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Media type:
E-Article
Title:
WCK 5222 (Cefepime-Zidebactam) Pharmacodynamic Target Analysis against Metallo-β-Lactamase-Producing Enterobacteriaceae in the Neutropenic Mouse Pneumonia Model
Contributor:
Lepak, Alexander J.;
Zhao, Miao;
Andes, David R.
imprint:
American Society for Microbiology, 2019
Published in:Antimicrobial Agents and Chemotherapy
Language:
English
DOI:
10.1128/aac.01648-19
ISSN:
0066-4804;
1098-6596
Origination:
Footnote:
Description:
<jats:p>WCK 5222 is a combination of cefepime and the novel β-lactam enhancer (BLE) zidebactam. Zidebactam has a dual mechanism of action involving high-affinity penicillin binding protein 2 (PBP2) binding as well as inhibition of Ambler class A and C enzymes.</jats:p>