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Torrentino-Madamet, Marylin; Collet, Louis; Lepère, Jean François; Benoit, Nicolas; Amalvict, Rémy; Ménard, Didier; Pradines, Bruno

K13-Propeller Polymorphisms in Plasmodium falciparum Isolates from Patients in Mayotte in 2013 and 2014

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  • Media type: E-Article
  • Title: K13-Propeller Polymorphisms in Plasmodium falciparum Isolates from Patients in Mayotte in 2013 and 2014
  • Contributor: Torrentino-Madamet, Marylin; Collet, Louis; Lepère, Jean François; Benoit, Nicolas; Amalvict, Rémy; Ménard, Didier; Pradines, Bruno
  • Published: American Society for Microbiology, 2015
  • Published in: Antimicrobial Agents and Chemotherapy, 59 (2015) 12, Seite 7878-7881
  • Language: English
  • DOI: 10.1128/aac.01251-15
  • ISSN: 0066-4804; 1098-6596
  • Keywords: Infectious Diseases ; Pharmacology (medical) ; Pharmacology
  • Origination:
  • Footnote:
  • Description: ABSTRACT Plasmodium falciparum isolates were collected from 29 malaria patients treated with artemether-lumefantrine in Mayotte in 2013 and 2014. Twenty-four cases (83%) consisted of imported malaria. Seventeen percent of the isolates presented mutations in one of the six K13-propeller blades (N490H, F495L, N554H/K, and E596G). A total of 23.8% of the isolates from the Union of Comoros showed K13-propeller polymorphisms. Three of the 18 isolates (16.7%) from Grande Comore showed polymorphisms (N490H, N554K, and E596G).
  • Access State: Open Access