Description:
<jats:title>ABSTRACT</jats:title>
<jats:p>
A library of compounds covering a broad chemical space was selected from a tuberculosis drug development program and was screened in a whole-cell assay against
<jats:named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">Mycobacterium ulcerans</jats:named-content>
, the causative agent of the necrotizing skin disease Buruli ulcer. While a number of potent antitubercular agents were only weakly active or inactive against
<jats:named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">M. ulcerans</jats:named-content>
, five compounds showed high activity (90% inhibitory concentration [IC
<jats:sub>90</jats:sub>
], ≤1 μM), making screening of focused antitubercular libraries a good starting point for lead generation against
<jats:named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">M. ulcerans</jats:named-content>
.
</jats:p>