Published:
American Society for Microbiology, 2012
Published in:
Antimicrobial Agents and Chemotherapy, 56 (2012) 6, Seite 3441-3443
Language:
English
DOI:
10.1128/aac.05682-11
ISSN:
0066-4804;
1098-6596
Origination:
Footnote:
Description:
ABSTRACT The interaction between colistin and tigecycline against eight well-characterized NDM-1-producing Enterobacteriaceae strains was studied. Time-kill methodology was employed using a 4-by-4 exposure matrix with pharmacokinetically achievable free drug peak, trough, and average 24-h serum concentrations. Colistin sulfate and methanesulfonate alone showed good early bactericidal activity, often with subsequent regrowth. Tigecycline alone had poor activity. Addition of tigecycline to colistin does not produce increased bacterial killing; instead, it may cause antagonism at lower concentrations.