Description:
<jats:title>ABSTRACT</jats:title>
<jats:p>
<jats:italic>Clostridium difficile</jats:italic>
remains the major cause of nosocomial diarrhea. Reports on impaired susceptibility of
<jats:italic>C. difficile</jats:italic>
to metronidazole and vancomycin and frequent relapses of patients after therapy necessitate the search for new substances. With this study, the activity of OPT-80, a new macrocycle, against 207
<jats:italic>C. difficile</jats:italic>
strains and against other obligately anaerobic bacteria was tested. OPT-80 showed high in vitro activity against all
<jats:italic>C. difficile</jats:italic>
strains tested.
</jats:p>