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Reinert, Ralf René; Al-Lahham, Adnan

Time-Kill Study of the Activity of Telithromycin against Macrolide-Resistant Streptococcus pneumoniae Isolates with 23S rRNA Mutations and Changes in Ribosomal Proteins L4 and L22

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  • Media type: E-Article
  • Title: Time-Kill Study of the Activity of Telithromycin against Macrolide-Resistant Streptococcus pneumoniae Isolates with 23S rRNA Mutations and Changes in Ribosomal Proteins L4 and L22
  • Contributor: Reinert, Ralf René; Al-Lahham, Adnan
  • Published: American Society for Microbiology, 2005
  • Published in: Antimicrobial Agents and Chemotherapy, 49 (2005) 7, Seite 3011-3013
  • Language: English
  • DOI: 10.1128/aac.49.7.3011-3013.2005
  • ISSN: 0066-4804; 1098-6596
  • Keywords: Infectious Diseases ; Pharmacology (medical) ; Pharmacology
  • Origination:
  • Footnote:
  • Description: <jats:title>ABSTRACT</jats:title> <jats:p> By use of a time-kill methodology, the antipneumococcal activity of telithromycin was determined against macrolide-resistant <jats:italic>S. pneumoniae</jats:italic> isolates having mutations in the 23S rRNA gene and changes in the ribosomal proteins L4 and L22. Telithromycin had MICs ranging between 0.03 and 0.25 μg/ml and was bactericidal against four of seven strains after 24 h at two times the MIC. </jats:p>
  • Access State: Open Access