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Media type:
E-Article
Title:
Inducement and Reversal of Tetracycline Resistance in Escherichia coli K-12 and Expression of Proton Gradient-Dependent Multidrug Efflux Pump Genes
Contributor:
Viveiros, Miguel;
Jesus, Ana;
Brito, Mafalda;
Leandro, Clara;
Martins, Marta;
Ordway, Diane;
Molnar, Ana Maria;
Molnar, Joseph;
Amaral, Leonard
imprint:
American Society for Microbiology, 2005
Published in:Antimicrobial Agents and Chemotherapy
Language:
English
DOI:
10.1128/aac.49.8.3578-3582.2005
ISSN:
0066-4804;
1098-6596
Origination:
Footnote:
Description:
<jats:title>ABSTRACT</jats:title>
<jats:p>
Expression of eight transporter genes of
<jats:italic>Escherichia coli</jats:italic>
K-12 and its Δ
<jats:italic>acrAB</jats:italic>
mutant prior to and after induction of both strains to tetracycline resistance and after reversal of induced resistance were analyzed by quantitative reverse transcriptase PCR. All transporter genes were overexpressed after induced resistance with
<jats:italic>acrF</jats:italic>
being 80-fold more expressed in the Δ
<jats:italic>acrAB</jats:italic>
tetracycline-induced strain.
</jats:p>