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Media type:
E-Article
Title:
Antibiotic Degradation by Commensal Microbes Shields Pathogens
Contributor:
Gjonbalaj, Mergim;
Keith, James W.;
Do, Mytrang H.;
Hohl, Tobias M.;
Pamer, Eric G.;
Becattini, Simone
imprint:
American Society for Microbiology, 2020
Published in:Infection and Immunity
Language:
English
DOI:
10.1128/iai.00012-20
ISSN:
1098-5522;
0019-9567
Origination:
Footnote:
Description:
<jats:p>
The complex bacterial populations that constitute the gut microbiota can harbor antibiotic resistance genes (ARGs), including those encoding β-lactamase enzymes (BLA), which degrade commonly prescribed antibiotics such as ampicillin. The prevalence of such genes in commensal bacteria has been increased in recent years by the wide use of antibiotics in human populations and in livestock. While transfer of ARGs between bacterial species has well-established dramatic public health implications, these genes can also function in
<jats:italic>trans</jats:italic>
within bacterial consortia, where antibiotic-resistant bacteria can provide antibiotic-sensitive neighbors with leaky protection from drugs, as shown both
<jats:italic>in vitro</jats:italic>
and
<jats:italic>in vivo</jats:italic>
, in models of lung and subcutaneous coinfection.
</jats:p>