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Birmes, Franziska S.; Säring, Ruth; Hauke, Miriam C.; Ritzmann, Niklas H.; Drees, Steffen L.; Daniel, Jens; Treffon, Janina; Liebau, Eva; Kahl, Barbara C.; Fetzner, Susanne

Interference with Pseudomonas aeruginosa Quorum Sensing and Virulence by the Mycobacterial Pseudomonas Quinolone Signal Dioxygenase AqdC in Combination with the N -Acylhomoserine Lactone Lactonase QsdA

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  • Media type: E-Article
  • Title: Interference with Pseudomonas aeruginosa Quorum Sensing and Virulence by the Mycobacterial Pseudomonas Quinolone Signal Dioxygenase AqdC in Combination with the N -Acylhomoserine Lactone Lactonase QsdA
  • Contributor: Birmes, Franziska S.; Säring, Ruth; Hauke, Miriam C.; Ritzmann, Niklas H.; Drees, Steffen L.; Daniel, Jens; Treffon, Janina; Liebau, Eva; Kahl, Barbara C.; Fetzner, Susanne
  • imprint: American Society for Microbiology, 2019
  • Published in: Infection and Immunity
  • Language: English
  • DOI: 10.1128/iai.00278-19
  • ISSN: 0019-9567; 1098-5522
  • Keywords: Infectious Diseases ; Immunology ; Microbiology ; Parasitology
  • Origination:
  • Footnote:
  • Description: <jats:p> The nosocomial pathogen <jats:named-content content-type="genus-species">Pseudomonas aeruginosa</jats:named-content> regulates its virulence via a complex quorum sensing network, which, besides <jats:italic>N</jats:italic> -acylhomoserine lactones, includes the alkylquinolone signal molecules 2-heptyl-3-hydroxy-4(1 <jats:italic>H</jats:italic> )-quinolone ( <jats:italic>Pseudomonas</jats:italic> quinolone signal [PQS]) and 2-heptyl-4(1 <jats:italic>H</jats:italic> )-quinolone (HHQ). <jats:named-content content-type="genus-species">Mycobacteroides abscessus</jats:named-content> subsp. <jats:italic>abscessus</jats:italic> , an emerging pathogen, is capable of degrading the PQS and also HHQ. Here, we show that although <jats:named-content content-type="genus-species">M. abscessus</jats:named-content> subsp. </jats:p>
  • Access State: Open Access