Description:
<jats:title>ABSTRACT</jats:title>
<jats:p>
Vaccination of mice with
<jats:italic>Escherichia coli</jats:italic>
expressing
<jats:italic>Brucella</jats:italic>
Cu/Zn superoxide dismutase (SOD) [
<jats:italic>E. coli</jats:italic>
(pBSSOD)] induced a significant level of protection against virulent
<jats:italic>Brucella abortus</jats:italic>
challenge, although this level was not as high as the one reached with
<jats:italic>B. abortus</jats:italic>
vaccine strain RB51. In addition, vaccination with
<jats:italic>E. coli</jats:italic>
(pBSSOD) induced antibodies to Cu/Zn SOD and a strong proliferative response of splenocytes when stimulated in vitro with a thioredoxin-Cu/Zn SOD fusion protein.
</jats:p>