Cody, Alison J.;
McCarthy, Noel M.;
Wimalarathna, Helen L.;
Colles, Frances M.;
Clark, Lorraine;
Bowler, Ian C. J. W.;
Maiden, Martin C. J.;
Dingle, Kate E.
A Longitudinal 6-Year Study of the Molecular Epidemiology of Clinical Campylobacter Isolates in Oxfordshire, United Kingdom
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Media type:
E-Article
Title:
A Longitudinal 6-Year Study of the Molecular Epidemiology of Clinical Campylobacter Isolates in Oxfordshire, United Kingdom
Contributor:
Cody, Alison J.;
McCarthy, Noel M.;
Wimalarathna, Helen L.;
Colles, Frances M.;
Clark, Lorraine;
Bowler, Ian C. J. W.;
Maiden, Martin C. J.;
Dingle, Kate E.
Description:
<jats:title>ABSTRACT</jats:title>
<jats:p>
Temporal and seasonal trends in
<jats:named-content content-type="genus-species">Campylobacter</jats:named-content>
genotypes causing human gastroenteritis were investigated in a 6-year study of 3,300 recent isolates from Oxfordshire, United Kingdom. Genotypes (sequence types [ST]) were defined using multilocus sequence typing and assigned to a clonal complex (a cluster of related strains that share four or more identical alleles with a previously defined central genotype). A previously undescribed clonal complex (ST-464) was identified which, together with ST-42, ST-45, and ST-52 complexes, showed increasing incidence. Concurrently, the incidence of ST-574, ST-607, and ST-658 complexes declined. The relative frequencies of three clonal complexes (ST-45, ST-283, and ST-42) peaked during summer and those of two (ST-353 and ST-403) peaked during winter. Nine clonal complexes (ST-22, ST-45, ST-48, ST-61, ST-257, ST-283, ST-403, ST-658, and ST-677) were significantly associated with ciprofloxacin sensitivity (
<jats:italic>P</jats:italic>
< 0.05). Seven clonal complexes (ST-49, ST-206, ST-354, ST-446, ST-460, ST-464, and ST-607) were associated with ciprofloxacin resistance (
<jats:italic>P</jats:italic>
< 0.05). Clonal complexes exhibited changing incidence and differences in seasonality and antibiotic resistance phenotype. These data also demonstrated that detailed surveillance at a single site captures information which reflects that observed nationally.
</jats:p>