Commichau, Fabian M.;
Heidemann, Jana L.;
Ficner, Ralf;
Stülke, Jörg
Making and Breaking of an Essential Poison: the Cyclases and Phosphodiesterases That Produce and Degrade the Essential Second Messenger Cyclic di-AMP in Bacteria
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Media type:
E-Article
Title:
Making and Breaking of an Essential Poison: the Cyclases and Phosphodiesterases That Produce and Degrade the Essential Second Messenger Cyclic di-AMP in Bacteria
Contributor:
Commichau, Fabian M.;
Heidemann, Jana L.;
Ficner, Ralf;
Stülke, Jörg
imprint:
American Society for Microbiology, 2019
Published in:Journal of Bacteriology
Language:
English
DOI:
10.1128/jb.00462-18
ISSN:
0021-9193;
1098-5530
Origination:
Footnote:
Description:
<jats:p>Cyclic di-AMP is a second-messenger nucleotide that is produced by many bacteria and some archaea. Recent work has shown that c-di-AMP is unique among the signaling nucleotides, as this molecule is in many bacteria both essential on one hand and toxic upon accumulation on the other.</jats:p>