Genome of the Opportunistic Pathogen Streptococcus sanguinis

Media type: E-Article
Title: Genome of the Opportunistic Pathogen Streptococcus sanguinis
Contributor: Xu, Ping; Alves, Joao M.; Kitten, Todd; Brown, Arunsri; Chen, Zhenming; Ozaki, Luiz S.; Manque, Patricio; Ge, Xiuchun; Serrano, Myrna G.; Puiu, Daniela; Hendricks, Stephanie; Wang, Yingping; Chaplin, Michael D.; Akan, Doruk; Paik, Sehmi; Peterson, Darrell L.; Macrina, Francis L.; Buck, Gregory A.
imprint: American Society for Microbiology, 2007
Published in: Journal of Bacteriology
Language: English
DOI: 10.1128/jb.01808-06
ISSN: 0021-9193; 1098-5530
Origination:
Footnote:
Description: <jats:title>ABSTRACT</jats:title> <jats:p> The genome of <jats:italic>Streptococcus sanguinis</jats:italic> is a circular DNA molecule consisting of 2,388,435 bp and is 177 to 590 kb larger than the other 21 streptococcal genomes that have been sequenced. The G+C content of the <jats:italic>S. sanguinis</jats:italic> genome is 43.4%, which is considerably higher than the G+C contents of other streptococci. The genome encodes 2,274 predicted proteins, 61 tRNAs, and four rRNA operons. A 70-kb region encoding pathways for vitamin B <jats:sub>12</jats:sub> biosynthesis and degradation of ethanolamine and propanediol was apparently acquired by horizontal gene transfer. The gene complement suggests new hypotheses for the pathogenesis and virulence of <jats:italic>S. sanguinis</jats:italic> and differs from the gene complements of other pathogenic and nonpathogenic streptococci. In particular, <jats:italic>S. sanguinis</jats:italic> possesses a remarkable abundance of putative surface proteins, which may permit it to be a primary colonizer of the oral cavity and agent of streptococcal endocarditis and infection in neutropenic patients. </jats:p>
Access State: Open Access

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