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Champiat, Stéphane; Garrison, Keith E.; Raposo, Rui André Saraiva; Burwitz, Benjamin J.; Reed, Jason; Tandon, Ravi; York, Vanessa A.; Newman, Laura P.; Nimityongskul, Francesca A.; Wilson, Nancy A.; Almeida, Rafael R.; Martin, Jeffrey N.; Deeks, Steven G.; Rosenberg, Michael G.; Wiznia, Andrew A.; Spotts, Gerald E.; Pilcher, Christopher D.; Hecht, Fredrick M.; Ostrowski, Mario A.; Sacha, Jonah B.; Nixon, Douglas F.

T Cells Target APOBEC3 Proteins in Human Immunodeficiency Virus Type 1-Infected Humans and Simian Immunodeficiency Virus-Infected Indian Rhesus Macaques

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  • Media type: E-Article
  • Title: T Cells Target APOBEC3 Proteins in Human Immunodeficiency Virus Type 1-Infected Humans and Simian Immunodeficiency Virus-Infected Indian Rhesus Macaques
  • Contributor: Champiat, Stéphane; Garrison, Keith E.; Raposo, Rui André Saraiva; Burwitz, Benjamin J.; Reed, Jason; Tandon, Ravi; York, Vanessa A.; Newman, Laura P.; Nimityongskul, Francesca A.; Wilson, Nancy A.; Almeida, Rafael R.; Martin, Jeffrey N.; Deeks, Steven G.; Rosenberg, Michael G.; Wiznia, Andrew A.; Spotts, Gerald E.; Pilcher, Christopher D.; Hecht, Fredrick M.; Ostrowski, Mario A.; Sacha, Jonah B.; Nixon, Douglas F.
  • Published: American Society for Microbiology, 2013
  • Published in: Journal of Virology, 87 (2013) 11, Seite 6073-6080
  • Language: English
  • DOI: 10.1128/jvi.00579-12
  • ISSN: 0022-538X; 1098-5514
  • Keywords: Virology ; Insect Science ; Immunology ; Microbiology
  • Origination:
  • Footnote:
  • Description: ABSTRACT APOBEC3 proteins mediate potent antiretroviral activity by hypermutating the retroviral genome during reverse transcription. To counteract APOBEC3 and gain a replicative advantage, lentiviruses such as human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) have evolved the Vif protein, which targets APOBEC3 proteins for proteasomal degradation. However, the proteasome plays a critical role in the generation of T cell peptide epitopes. Whether Vif-mediated destruction of APOBEC3 proteins leads to the generation and presentation of APOBEC3-derived T cell epitopes on the surfaces of lentivirus-infected cells remains unknown. Here, using peptides derived from multiple Vif-sensitive APOBEC3 proteins, we identified APOBEC3-specific T cell responses in both HIV-1-infected patients and SIV-infected rhesus macaques. These results raise the possibility that these T cell responses may be part of the larger antiretroviral immune response.
  • Access State: Open Access