You can manage bookmarks using lists, please log in to your user account for this.
Media type:
E-Article
Title:
Influenza A Virus M2 Protein Apical Targeting Is Required for Efficient Virus Replication
Contributor:
Wohlgemuth, Nicholas;
Lane, Andrew P.;
Pekosz, Andrew
imprint:
American Society for Microbiology, 2018
Published in:Journal of Virology
Language:
English
DOI:
10.1128/jvi.01425-18
ISSN:
0022-538X;
1098-5514
Origination:
Footnote:
Description:
<jats:p>Influenza A virus assembly and particle release occur at the apical membrane of polarized epithelial cells. The integral membrane proteins encoded by the virus, HA, NA, and M2, are all targeted to the apical membrane and believed to recruit the other structural proteins to sites of virus assembly. By targeting M2 to the basolateral or endoplasmic reticulum membranes, influenza A virus replication was significantly reduced. Basolateral targeting of M2 reduced the infectious virus titers with minimal effects on virus particle release, while targeting to the endoplasmic reticulum resulted in reduced infectious and total virus particle release. Therefore, altering the expression and the intracellular targeting of M2 has major effects on virus replication.</jats:p>