> Details

Vallbracht, Melina; Lötzsch, Henriette; Klupp, Barbara G.; Fuchs, Walter; Vollmer, Benjamin; Grünewald, Kay; Backovic, Marija; Rey, Felix A.; Mettenleiter, Thomas C.

In Vitro Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry

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  • Media type: E-Article
  • Title: In Vitro Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry
  • Contributor: Vallbracht, Melina; Lötzsch, Henriette; Klupp, Barbara G.; Fuchs, Walter; Vollmer, Benjamin; Grünewald, Kay; Backovic, Marija; Rey, Felix A.; Mettenleiter, Thomas C.
  • Published: American Society for Microbiology, 2021
  • Published in: mBio, 12 (2021) 3
  • Language: English
  • DOI: 10.1128/mbio.00557-21
  • ISSN: 2150-7511
  • Keywords: Virology ; Microbiology
  • Origination:
  • Footnote:
  • Description: <jats:p>The class III fusion protein glycoprotein B (gB) drives membrane fusion during entry and spread of herpesviruses. To mediate fusion, gB requires activation by the conserved gH/gL complex by a poorly defined mechanism.</jats:p>
  • Access State: Open Access