Evans, Heather M.;
Schultz, Destiny F.;
Boiman, Adam J.;
McKell, Melanie C.;
Qualls, Joseph E.;
Deepe, George S.
Restraint of Fumarate Accrual by HIF-1α Preserves miR-27a-Mediated Limitation of Interleukin 10 during Infection of Macrophages by Histoplasma capsulatum
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Media type:
E-Article
Title:
Restraint of Fumarate Accrual by HIF-1α Preserves miR-27a-Mediated Limitation of Interleukin 10 during Infection of Macrophages by Histoplasma capsulatum
Contributor:
Evans, Heather M.;
Schultz, Destiny F.;
Boiman, Adam J.;
McKell, Melanie C.;
Qualls, Joseph E.;
Deepe, George S.
imprint:
American Society for Microbiology, 2021
Published in:mBio
Language:
English
DOI:
10.1128/mbio.02710-21
ISSN:
2150-7511
Origination:
Footnote:
Description:
<jats:p><jats:named-content content-type="genus-species">Histoplasma capsulatum</jats:named-content>and related<jats:italic>Histoplasma</jats:italic>species are intracellular fungal pathogens endemic to broad regions of the globe, including the Americas, Africa, and Asia. While most infections resolve with mild or no symptoms, failure of the host to control fungal growth produces severe disease.</jats:p>