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Media type:
E-Article
Title:
CRISPR Interference of a Clonally Variant GC-Rich Noncoding RNA Family Leads to General Repression of var Genes in Plasmodium falciparum
Contributor:
Barcons-Simon, Anna;
Cordon-Obras, Carlos;
Guizetti, Julien;
Bryant, Jessica M.;
Scherf, Artur
Published:
American Society for Microbiology, 2020
Published in:
mBio, 11 (2020) 1
Language:
English
DOI:
10.1128/mbio.03054-19
ISSN:
2161-2129;
2150-7511
Origination:
Footnote:
Description:
<jats:p>
<jats:named-content content-type="genus-species">Plasmodium falciparum</jats:named-content>
is the deadliest malaria parasite species, accounting for the vast majority of disease cases and deaths. The virulence of this parasite is reliant upon the mutually exclusive expression of cytoadherence proteins encoded by the 60-member
<jats:italic>var</jats:italic>
gene family. Antigenic variation of this multigene family serves as an immune evasion mechanism, ultimately leading to chronic infection and pathogenesis. Understanding the regulation mechanism of antigenic variation is key to developing new therapeutic and control strategies. Our study uncovers a novel layer in the epigenetic regulation of transcription of this family of virulence genes by means of a multigene-targeting CRISPR interference approach.
</jats:p>