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Cian, Melina B.; Mettlach, Joshua A.; Zahn, Aaron E.; Giordano, Nicole P.; Minor, Keaton E.; McClelland, Michael; Dalebroux, Zachary D.

Cardiolipin Biosynthesis Genes Are Not Required for Salmonella enterica Serovar Typhimurium Pathogenesis in C57BL/6J Mice

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  • Media type: E-Article
  • Title: Cardiolipin Biosynthesis Genes Are Not Required for Salmonella enterica Serovar Typhimurium Pathogenesis in C57BL/6J Mice
  • Contributor: Cian, Melina B.; Mettlach, Joshua A.; Zahn, Aaron E.; Giordano, Nicole P.; Minor, Keaton E.; McClelland, Michael; Dalebroux, Zachary D.
  • imprint: American Society for Microbiology, 2022
  • Published in: Microbiology Spectrum
  • Language: English
  • DOI: 10.1128/spectrum.02617-21
  • ISSN: 2165-0497
  • Keywords: Infectious Diseases ; Cell Biology ; Microbiology (medical) ; Genetics ; General Immunology and Microbiology ; Ecology ; Physiology
  • Origination:
  • Footnote:
  • Description: <jats:p> <jats:named-content content-type="genus-species">Salmonella enterica</jats:named-content> serovar Typhimurium is a pathogenic Gram-negative bacterium that regulates the cardiolipin (CL) and lipopolysaccharide (LPS) composition of the outer membrane (OM) during infection. Mitochondrial CL molecules activate the inflammasome and its effector caspase-1, which initiates an inflammatory process called pyroptosis. </jats:p>
  • Access State: Open Access