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Pezzini, Alessandro; Tarantino, Barbara; Zedde, Maria Luisa; Marcheselli, Simona; Silvestrelli, Giorgio; Ciccone, Alfonso; Delodovici, Maria Luisa; Princiotta Cariddi, Lucia; Vidale, Simone; Paciaroni, Maurizio; Azzini, Cristiano; Padroni, Marina; Gamba, Massimo; Magoni, Mauro; Del Sette, Massimo; Tassi, Rossana; de Franco, Ivo Giuseppe; Cavallini, Anna; Calabrò, Rocco Salvatore; Cappellari, Manuel; Giorli, Elisa; Giacalone, Giacomo; Lodigiani, Corrado; Zenorini, Mara; [...]

Statin use and long-term risk of recurrent intracerebral haemorrhage: the MUCH-Italy

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  • Media type: E-Article
  • Title: Statin use and long-term risk of recurrent intracerebral haemorrhage: the MUCH-Italy
  • Contributor: Pezzini, Alessandro; Tarantino, Barbara; Zedde, Maria Luisa; Marcheselli, Simona; Silvestrelli, Giorgio; Ciccone, Alfonso; Delodovici, Maria Luisa; Princiotta Cariddi, Lucia; Vidale, Simone; Paciaroni, Maurizio; Azzini, Cristiano; Padroni, Marina; Gamba, Massimo; Magoni, Mauro; Del Sette, Massimo; Tassi, Rossana; de Franco, Ivo Giuseppe; Cavallini, Anna; Calabrò, Rocco Salvatore; Cappellari, Manuel; Giorli, Elisa; Giacalone, Giacomo; Lodigiani, Corrado; Zenorini, Mara; [...]
  • Published: BMJ, 2024
  • Published in: Journal of Neurology, Neurosurgery & Psychiatry (2024), Seite jnnp-2024-333396
  • Language: English
  • DOI: 10.1136/jnnp-2024-333396
  • ISSN: 0022-3050; 1468-330X
  • Origination:
  • Footnote:
  • Description: BackgroundWhether statin use after spontaneous intracerebral haemorrhage (ICH) increases the risk of recurrent ICH is uncertain.MethodsIn the setting of the Multicentric Study on Cerebral Haemorrhage in Italy we followed up a cohort of 30-day ICH survivors, consecutively admitted from January 2002 to July 2014, to assess whether the use of statins after the acute event is associated with recurrent cerebral bleeding.Results1623 patients (mean age, 73.9±10.3 years; males, 55.9%) qualified for the analysis. After a median follow-up of 40.5 months (25th to 75th percentile, 67.7) statin use was not associated with increased risk of recurrent ICH either in the whole study group (adjusted HR, 0.99; 95% CI 0.64 to 1.53) or in the subgroups defined by haematoma location (deep ICH, adjusted HR, 0.74; 95% CI 0.35 to 1.57; lobar ICH, adjusted HR, 1.09; 95% CI 0.62 to 1.90), intensity of statins (low-moderate intensity statins, adjusted HR, 0.93; 95% CI 0.58 to 1.49; high-intensity statins, adjusted HR, 1.48; 95% CI 0.66 to 3.31) and use of statins before the index event (adjusted HR, 0.66; 95% CI 0.38 to 1.17).ConclusionsStatin use appears to be unrelated to the risk of ICH recurrence.