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Media type:
E-Article
Title:
Wnt signaling and its downstream target N-myc regulate basal progenitors in the developing neocortex
Contributor:
Kuwahara, Atsushi;
Hirabayashi, Yusuke;
Knoepfler, Paul S.;
Taketo, Makoto M.;
Sakai, Juro;
Kodama, Tatsuhiko;
Gotoh, Yukiko
Published:
The Company of Biologists, 2010
Published in:
Development, 137 (2010) 7, Seite 1035-1044
Language:
English
DOI:
10.1242/dev.046417
ISSN:
1477-9129;
0950-1991
Origination:
Footnote:
Description:
<jats:p>Basal progenitors (also called non-surface dividing or intermediate progenitors) have been proposed to regulate the number of neurons during neocortical development through expanding cells committed to a neuronal fate, although the signals that govern this population have remained largely unknown. Here, we show that N-myc mediates the functions of Wnt signaling in promoting neuronal fate commitment and proliferation of neural precursor cells in vitro. Wnt signaling and N-myc also contribute to the production of basal progenitors in vivo. Expression of a stabilized form of β-catenin, a component of the Wnt signaling pathway, or of N-myc increased the numbers of neocortical basal progenitors, whereas conditional deletion of the N-myc gene reduced these and, as a likely consequence, the number of neocortical neurons. These results reveal that Wnt signaling via N-myc is crucial for the control of neuron number in the developing neocortex.</jats:p>