• Media type: E-Article
  • Title: Towards understanding paternal extragenic contributions to early amphibian pattern specification: the axolotl ts—1 gene as a model system
  • Contributor: Malacinski, George M.; Barone, Dorothy
  • imprint: The Company of Biologists, 1985
  • Published in: Development
  • Language: English
  • DOI: 10.1242/dev.89.supplement.53
  • ISSN: 0950-1991; 1477-9129
  • Keywords: Developmental Biology ; Molecular Biology
  • Origination:
  • Footnote:
  • Description: <jats:title>ABSTRACT</jats:title> <jats:p>As a model system for understanding the role sperm extragenic components might play in early embryogenesis the genetics and phenotype of the ts—1 axolotl (Ambystoma mexicanum) mutant gene are reviewed. That mutant gene displays parental effects. It exhibits both maternal (egg-mediated) as well as paternal (sperm-mediated) phenotypic effects. A variety of possible modes of action of the ts—1 gene are reviewed. Comparisons of various precedents to the ts—1 genetic data are made. In addition, novel models which account for the ts—1 phenotypic data are presented.</jats:p>
  • Access State: Open Access