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Media type:
E-Article
Title:
Local cAMP signaling in disease at a glance
Contributor:
Gold, Matthew G.;
Gonen, Tamir;
Scott, John D.
Published:
The Company of Biologists, 2013
Published in:
Journal of Cell Science, 126 (2013) 20, Seite 4537-4543
Language:
English
DOI:
10.1242/jcs.133751
ISSN:
1477-9137;
0021-9533
Origination:
Footnote:
Description:
Summary The second messenger cyclic AMP (cAMP) operates in discrete subcellular regions within which proteins that synthesize, break down or respond to the second messenger are precisely organized. A burgeoning knowledge of compartmentalized cAMP signaling is revealing how the local control of signaling enzyme activity impacts upon disease. The aim of this Cell Science at a Glance article and the accompanying poster is to highlight how misregulation of local cyclic AMP signaling can have pathophysiological consequences. We first introduce the core molecular machinery for cAMP signaling, which includes the cAMP-dependent protein kinase (PKA), and then consider the role of A-kinase anchoring proteins (AKAPs) in coordinating different cAMP-responsive proteins. The latter sections illustrate the emerging role of local cAMP signaling in four disease areas: cataracts, cancer, diabetes and cardiovascular diseases.