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Habota, Tina; Sandu, Anca-Larisa; Waiter, Gordon D.; McNeil, Christopher J.; Steele, J. Douglas; Macfarlane, Jennifer A.; Whalley, Heather C.; Valentine, Ruth; Younie, Dawn; Crouch, Nichola; Hawkins, Emma L.; Hirose, Yoriko; Romaniuk, Liana; Milburn, Keith; Buchan, Gordon; Coupar, Tessa; Stirling, Mairi; Jagpal, Baljit; MacLennan, Beverly; Priba, Lucasz; Harris, Mathew A.; Hafferty, Jonathan D.; Adams, Mark J.; Campbell, Archie I.; [...]

Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments

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  • Media type: E-Article
  • Title: Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments
  • Contributor: Habota, Tina; Sandu, Anca-Larisa; Waiter, Gordon D.; McNeil, Christopher J.; Steele, J. Douglas; Macfarlane, Jennifer A.; Whalley, Heather C.; Valentine, Ruth; Younie, Dawn; Crouch, Nichola; Hawkins, Emma L.; Hirose, Yoriko; Romaniuk, Liana; Milburn, Keith; Buchan, Gordon; Coupar, Tessa; Stirling, Mairi; Jagpal, Baljit; MacLennan, Beverly; Priba, Lucasz; Harris, Mathew A.; Hafferty, Jonathan D.; Adams, Mark J.; Campbell, Archie I.; [...]
  • Published: F1000 Research Ltd, 2019
  • Published in: Wellcome Open Research, 4 (2019), Seite 185
  • Language: English
  • DOI: 10.12688/wellcomeopenres.15538.1
  • ISSN: 2398-502X
  • Keywords: General Biochemistry, Genetics and Molecular Biology ; Medicine (miscellaneous)
  • Origination:
  • Footnote:
  • Description: <ns4:p>STratifying Resilience and Depression Longitudinally (STRADL) is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL is to subtype major depressive disorder (MDD) on the basis of its aetiology, using detailed clinical, cognitive, and brain imaging assessments. The GS:SFHS provides an important opportunity to study complex gene-environment interactions, incorporating linkage to existing datasets and inclusion of early-life variables for two longitudinal birth cohorts. Specifically, data collection in STRADL included: socio-economic and lifestyle variables; physical measures; questionnaire data that assesses resilience, early-life adversity, personality, psychological health, and lifetime history of mood disorder; laboratory samples; cognitive tests; and brain magnetic resonance imaging. Some of the questionnaire and cognitive data were first assessed at the GS:SFHS baseline assessment between 2006-2011, thus providing longitudinal measures of depression and resilience. Similarly, routine NHS data and early-life variables are linked to STRADL data, further providing opportunities for longitudinal analysis. Recruitment has been completed and we consented and tested 1,188 participants.</ns4:p>
  • Access State: Open Access