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Malone, Kathleen E.; Begg, Colin B.; Haile, Robert W.; Borg, Ake; Concannon, Patrick; Tellhed, Lina; Xue, Shanyan; Teraoka, Sharon; Bernstein, Leslie; Capanu, Marinela; Reiner, Anne S.; Riedel, Elyn R.; Thomas, Duncan C.; Mellemkjær, Lene; Lynch, Charles F.; Boice, John D.; Anton-Culver, Hoda; Bernstein, Jonine L.

Population-Based Study of the Risk of Second Primary Contralateral Breast Cancer Associated With Carrying a Mutation inBRCA1orBRCA2

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  • Media type: E-Article
  • Title: Population-Based Study of the Risk of Second Primary Contralateral Breast Cancer Associated With Carrying a Mutation inBRCA1orBRCA2
  • Contributor: Malone, Kathleen E.; Begg, Colin B.; Haile, Robert W.; Borg, Ake; Concannon, Patrick; Tellhed, Lina; Xue, Shanyan; Teraoka, Sharon; Bernstein, Leslie; Capanu, Marinela; Reiner, Anne S.; Riedel, Elyn R.; Thomas, Duncan C.; Mellemkjær, Lene; Lynch, Charles F.; Boice, John D.; Anton-Culver, Hoda; Bernstein, Jonine L.
  • Published: American Society of Clinical Oncology (ASCO), 2010
  • Published in: Journal of Clinical Oncology, 28 (2010) 14, Seite 2404-2410
  • Language: English
  • DOI: 10.1200/jco.2009.24.2495
  • ISSN: 1527-7755; 0732-183X
  • Origination:
  • Footnote:
  • Description: PurposeWomen with breast cancer diagnosed early in life comprise a substantial portion of those tested for BRCA1/BRCA2 mutations; however, little information is available on the subsequent risks of contralateral breast cancer in mutation carriers. This study assessed the risk of subsequent contralateral breast cancer associated with carrying a BRCA1 or BRCA2 mutation.Patients and MethodsIn this nested case-control study, patients with contralateral breast cancer diagnosed 1 year or more after a first primary breast cancer (n = 705) and controls with unilateral breast cancer (n = 1,398) were ascertained from an underlying population-based cohort of 52,536 women diagnosed with a first invasive breast cancer before age 55 years. Interviews and medical record reviews were used to collect risk factor and treatment histories. All women were tested for BRCA1/BRCA2 mutations. Relative (rate ratios) and absolute (5- and 10-year cumulative) risks of developing contralateral breast cancer following a first invasive breast cancer were computed.ResultsCompared with noncarriers, BRCA1 and BRCA2 mutation carriers had 4.5-fold (95% CI, 2.8- to 7.1-fold) and 3.4-fold (95% CI, 2.0- to 5.8-fold) increased risks of contralateral breast cancer, respectively. The relative risk of contralateral breast cancer for BRCA1 mutation carriers increased as age of first diagnosis decreased. Age-specific cumulative risks are provided for clinical guidance.ConclusionThe risks of subsequent contralateral breast cancer are substantial for women who carry a BRCA1/BRCA2 mutation. These findings have important clinical relevance regarding the assessment of BRCA1/BRCA2 status in patients with breast cancer and the counseling and clinical management of patients found to carry a mutation.
  • Access State: Open Access