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Kyriakopoulos, Christos E.; Chen, Yu-Hui; Carducci, Michael A.; Liu, Glenn; Jarrard, David F.; Hahn, Noah M.; Shevrin, Daniel H.; Dreicer, Robert; Hussain, Maha; Eisenberger, Mario; Kohli, Manish; Plimack, Elizabeth R.; Vogelzang, Nicholas J.; Picus, Joel; Cooney, Matthew M.; Garcia, Jorge A.; DiPaola, Robert S.; Sweeney, Christopher J.

Chemohormonal Therapy in Metastatic Hormone-Sensitive Prostate Cancer: Long-Term Survival Analysis of the Randomized Phase III E3805 CHAARTED Trial

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  • Media type: E-Article
  • Title: Chemohormonal Therapy in Metastatic Hormone-Sensitive Prostate Cancer: Long-Term Survival Analysis of the Randomized Phase III E3805 CHAARTED Trial
  • Contributor: Kyriakopoulos, Christos E.; Chen, Yu-Hui; Carducci, Michael A.; Liu, Glenn; Jarrard, David F.; Hahn, Noah M.; Shevrin, Daniel H.; Dreicer, Robert; Hussain, Maha; Eisenberger, Mario; Kohli, Manish; Plimack, Elizabeth R.; Vogelzang, Nicholas J.; Picus, Joel; Cooney, Matthew M.; Garcia, Jorge A.; DiPaola, Robert S.; Sweeney, Christopher J.
  • Published: American Society of Clinical Oncology (ASCO), 2018
  • Published in: Journal of Clinical Oncology, 36 (2018) 11, Seite 1080-1087
  • Language: English
  • DOI: 10.1200/jco.2017.75.3657
  • ISSN: 0732-183X; 1527-7755
  • Origination:
  • Footnote:
  • Description: PurposeDocetaxel added to androgen-deprivation therapy (ADT) significantly increases the longevity of some patients with metastatic hormone-sensitive prostate cancer. Herein, we present the outcomes of the CHAARTED (Chemohormonal Therapy Versus Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer) trial with more mature follow-up and focus on tumor volume.Patients and MethodsIn this phase III study, 790 patients with metastatic hormone-sensitive prostate cancer were equally randomly assigned to receive either ADT in combination with docetaxel 75 mg/m2for up to six cycles or ADT alone. The primary end point of the study was overall survival (OS). Additional analyses of the prospectively defined low- and high-volume disease subgroups were performed. High-volume disease was defined as presence of visceral metastases and/or ≥ four bone metastases with at least one outside of the vertebral column and pelvis.ResultsAt a median follow-up of 53.7 months, the median OS was 57.6 months for the chemohormonal therapy arm versus 47.2 months for ADT alone (hazard ratio [HR], 0.72; 95% CI, 0.59 to 0.89; P = .0018). For patients with high-volume disease (n = 513), the median OS was 51.2 months with chemohormonal therapy versus 34.4 months with ADT alone (HR, 0.63; 95% CI, 0.50 to 0.79; P < .001). For those with low-volume disease (n = 277), no OS benefit was observed (HR, 1.04; 95% CI, 0.70 to 1.55; P = .86).ConclusionThe clinical benefit from chemohormonal therapy in prolonging OS was confirmed for patients with high-volume disease; however, for patients with low-volume disease, no OS benefit was discerned.
  • Access State: Open Access