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Sanft, Tara; Harrigan, Maura; McGowan, Courtney; Cartmel, Brenda; Zupa, Michelle; Li, Fang-Yong; Ferrucci, Leah M.; Puklin, Leah; Cao, Anlan; Nguyen, Thai Hien; Neuhouser, Marian L.; Hershman, Dawn L.; Basen-Engquist, Karen; Jones, Beth A.; Knobf, Tish; Chagpar, Anees B.; Silber, Andrea; Tanasijevic, Anna; Ligibel, Jennifer A.; Irwin, Melinda L.

Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study

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  • Media type: E-Article
  • Title: Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study
  • Contributor: Sanft, Tara; Harrigan, Maura; McGowan, Courtney; Cartmel, Brenda; Zupa, Michelle; Li, Fang-Yong; Ferrucci, Leah M.; Puklin, Leah; Cao, Anlan; Nguyen, Thai Hien; Neuhouser, Marian L.; Hershman, Dawn L.; Basen-Engquist, Karen; Jones, Beth A.; Knobf, Tish; Chagpar, Anees B.; Silber, Andrea; Tanasijevic, Anna; Ligibel, Jennifer A.; Irwin, Melinda L.
  • imprint: American Society of Clinical Oncology (ASCO), 2023
  • Published in: Journal of Clinical Oncology
  • Language: English
  • DOI: 10.1200/jco.23.00871
  • ISSN: 0732-183X; 1527-7755
  • Origination:
  • Footnote:
  • Description: <jats:sec><jats:title>PURPOSE</jats:title><jats:p> Successful completion of chemotherapy is critical to improve breast cancer outcomes. Relative dose intensity (RDI), defined as the ratio of chemotherapy delivered to prescribed, is a measure of chemotherapy completion and is associated with cancer mortality. The effect of exercise and eating a healthy diet on RDI is unknown. We conducted a randomized trial of an exercise and nutrition intervention on RDI and pathologic complete response (pCR) in women diagnosed with breast cancer initiating chemotherapy. </jats:p></jats:sec><jats:sec><jats:title>METHODS</jats:title><jats:p> One hundred seventy-three women with stage I-III breast cancer were randomly assigned to usual care (UC; n = 86) or a home-based exercise and nutrition intervention with counseling sessions delivered by oncology-certified registered dietitians (n = 87). Chemotherapy dose adjustments and delays and pCR were abstracted from electronic medical records. T-tests and chi-square tests were used to examine the effect of the intervention versus UC on RDI and pCR. </jats:p></jats:sec><jats:sec><jats:title>RESULTS</jats:title><jats:p> Participants randomly assigned to intervention had greater improvements in exercise and diet quality compared with UC ( P &lt; .05). RDI was 92.9% ± 12.1% and 93.6% ± 11.1% for intervention and UC, respectively ( P = .69); the proportion of patients in the intervention versus UC who achieved ≥85% RDI was 81% and 85%, respectively ( P = .44). The proportion of patients who had at least one dose reduction and/or delay was 38% intervention and 36% UC ( P = .80). Among 72 women who received neoadjuvant chemotherapy, women randomly assigned to intervention were more likely to have a pCR than those randomly assigned to UC (53% v 28%; P = .037). </jats:p></jats:sec><jats:sec><jats:title>CONCLUSION</jats:title><jats:p> Although a diet and exercise intervention did not affect RDI, the intervention was associated with a higher pCR in patients with hormone receptor–positive/human epidermal growth factor receptor 2–negative and triple-negative breast cancer undergoing neoadjuvant chemotherapy. </jats:p></jats:sec>