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Media type:
E-Article
Title:
Genetic dissection of complex traits using hierarchical biological knowledge
Contributor:
Tanaka, Hidenori;
Kreisberg, Jason F.;
Ideker, Trey
Published:
Public Library of Science (PLoS), 2021
Published in:
PLOS Computational Biology, 17 (2021) 9, Seite e1009373
Language:
English
DOI:
10.1371/journal.pcbi.1009373
ISSN:
1553-7358
Origination:
Footnote:
Description:
Despite the growing constellation of genetic loci linked to common traits, these loci have yet to account for most heritable variation, and most act through poorly understood mechanisms. Recent machine learning (ML) systems have used hierarchical biological knowledge to associate genetic mutations with phenotypic outcomes, yielding substantial predictive power and mechanistic insight. Here, we use an ontology-guided ML system to map single nucleotide variants (SNVs) focusing on 6 classic phenotypic traits in natural yeast populations. The 29 identified loci are largely novel and account for ~17% of the phenotypic variance, versus <3% for standard genetic analysis. Representative results show that sensitivity to hydroxyurea is linked to SNVs in two alternative purine biosynthesis pathways, and that sensitivity to copper arises through failure to detoxify reactive oxygen species in fatty acid metabolism. This work demonstrates a knowledge-based approach to amplifying and interpreting signals in population genetic studies.