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Thach, Tran Quang; Eisa, Heba Gamal; Hmeda, AlMotsim Ben; Faraj, Hazem; Thuan, Tieu Minh; Abdelrahman, Manal Mahmoud; Awadallah, Mario Gerges; Ha, Nam Xuan; Noeske, Michael; Abdul Aziz, Jeza Muhamad; Nam, Nguyen Hai; Nile, Mohamed El; Dumre, Shyam Prakash; Huy, Nguyen Tien; Hirayama, Kenji

Predictive markers for the early prognosis of dengue severity: A systematic review and meta-analysis

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  • Media type: E-Article
  • Title: Predictive markers for the early prognosis of dengue severity: A systematic review and meta-analysis
  • Contributor: Thach, Tran Quang; Eisa, Heba Gamal; Hmeda, AlMotsim Ben; Faraj, Hazem; Thuan, Tieu Minh; Abdelrahman, Manal Mahmoud; Awadallah, Mario Gerges; Ha, Nam Xuan; Noeske, Michael; Abdul Aziz, Jeza Muhamad; Nam, Nguyen Hai; Nile, Mohamed El; Dumre, Shyam Prakash; Huy, Nguyen Tien; Hirayama, Kenji
  • imprint: Public Library of Science (PLoS), 2021
  • Published in: PLOS Neglected Tropical Diseases
  • Language: English
  • DOI: 10.1371/journal.pntd.0009808
  • ISSN: 1935-2735
  • Origination:
  • Footnote:
  • Description: <jats:sec id="sec001"><jats:title>Background</jats:title><jats:p>Predictive markers represent a solution for the proactive management of severe dengue. Despite the low mortality rate resulting from severe cases, dengue requires constant examination and round-the-clock nursing care due to the unpredictable progression of complications, posing a burden on clinical triage and material resources. Accordingly, identifying markers that allow for predicting disease prognosis from the initial diagnosis is needed. Given the improved pathogenesis understanding, myriad candidates have been proposed to be associated with severe dengue progression. Thus, we aim to review the relationship between the available biomarkers and severe dengue.</jats:p></jats:sec><jats:sec id="sec002"><jats:title>Methodology</jats:title><jats:p>We performed a systematic review and meta-analysis to compare the differences in host data collected within 72 hours of fever onset amongst the different disease severity levels. We searched nine bibliographic databases without restrictive criteria of language and publication date. We assessed risk of bias and graded robustness of evidence using NHLBI quality assessments and GRADE, respectively. This study protocol is registered in PROSPERO (CRD42018104495).</jats:p></jats:sec><jats:sec id="sec003"><jats:title>Principal findings</jats:title><jats:p>Of 4000 records found, 40 studies for qualitative synthesis, 19 for meta-analysis. We identified 108 host and viral markers collected within 72 hours of fever onset from 6160 laboratory-confirmed dengue cases, including hematopoietic parameters, biochemical substances, clinical symptoms, immune mediators, viral particles, and host genes. Overall, inconsistent case classifications explained substantial heterogeneity, and meta-analyses lacked statistical power. Still, moderate-certainty evidence indicated significantly lower platelet counts (SMD -0.65, 95% CI -0.97 to -0.32) and higher AST levels (SMD 0.87, 95% CI 0.36 to 1.38) in severe cases when compared to non-severe dengue during this time window.</jats:p></jats:sec><jats:sec id="sec004"><jats:title>Conclusion</jats:title><jats:p>The findings suggest that alterations of platelet count and AST level—in the first 72 hours of fever onset—are independent markers predicting the development of severe dengue.</jats:p></jats:sec>
  • Access State: Open Access