> Details

Sandes-Freitas, Tainá Veras de; Moura, Lucio Requião; Carvalho, Deise Rosa de Boni Monteiro de; Garcia, Valter Duro; Modelli de Andrade, Luis Gustavo; Mazzali, Marilda; Manfro, Roberto Ceratti; Deboni, Luciane Mônica; Davi-Neto, Elias; Oliveira, Claudia Maria Costa de; Cavalcanti, Frederico Castelo Branco; Madeira, Rafael Lage; Esmeraldo, Ronaldo de Matos; Simão, Denise Rodrigues; Meira, Ana Carolina Guedes; Ferreira, Gustavo Fernandes; Lasmar, Marcus; Bignelli, Alexandre Tortoza; Pacheco-Silva, Alvaro; Medina Pestana, José; Tedesco Silva, Hélio

The impact of preservation solutions for static cold storage on kidney transplantation outcomes: Results of a Brazilian nationwide multicenter study

Reference
management

Bookmarks

Remove from
bookmarks

Share this on Whatsapp

Close

Bookmarks



You can manage bookmarks using lists, please log in to your user account for this.
  • Media type: E-Article
  • Title: The impact of preservation solutions for static cold storage on kidney transplantation outcomes: Results of a Brazilian nationwide multicenter study
  • Contributor: Sandes-Freitas, Tainá Veras de; Moura, Lucio Requião; Carvalho, Deise Rosa de Boni Monteiro de; Garcia, Valter Duro; Modelli de Andrade, Luis Gustavo; Mazzali, Marilda; Manfro, Roberto Ceratti; Deboni, Luciane Mônica; Davi-Neto, Elias; Oliveira, Claudia Maria Costa de; Cavalcanti, Frederico Castelo Branco; Madeira, Rafael Lage; Esmeraldo, Ronaldo de Matos; Simão, Denise Rodrigues; Meira, Ana Carolina Guedes; Ferreira, Gustavo Fernandes; Lasmar, Marcus; Bignelli, Alexandre Tortoza; Pacheco-Silva, Alvaro; Medina Pestana, José; Tedesco Silva, Hélio
  • Published: Public Library of Science (PLoS), 2024
  • Published in: PLOS ONE, 19 (2024) 7, Seite e0306056
  • Language: English
  • DOI: 10.1371/journal.pone.0306056
  • ISSN: 1932-6203
  • Origination:
  • Footnote:
  • Description: This study evaluated the current practices of selecting cold storage preservation solutions in Brazil and their impact on delayed graft function (DGF) incidence and 1-year outcomes in kidney transplant recipients. A retrospective cohort study was conducted, including 3,134 brain-dead deceased donor kidney transplants performed between 2014 and 2015 in 18 Brazilian centers. The most commonly used preservation solution was Euro-collins (EC, 55.4%), followed by Histidine-tryptophan-ketoglutarate (HTK, 30%) and Institut Georges Lopez (IGL-1, 14.6%). The incidence of DGF was 54.4%, with 11.7% of patients requiring dialysis for more than 14 days, indicating prolonged DGF. Upon adjusting for confounding variables, HTK demonstrated a significantly lower risk of DGF than EC (OR 0.7350.82500.926), as did IGL-1 (OR 0.6050.7120.837). Similar protective effects were observed for prolonged DGF when comparing HTK (OR 0.4780.5990.749) and IGL-1 (OR 0.4780.6810.749) against EC. No significant association was found between preservation solutions and 1-year death-censored graft survival. In conclusion, EC was the most frequently used cold storage perfusion solution, demonstrating a higher incidence and duration of DGF compared with HTK and IGL-1, but with no impact on 1-year graft survival.
  • Access State: Open Access