Amitay, Efrat L.;
Carr, Prudence R.;
Gies, Anton;
Laetsch, Dana Clarissa;
Brenner, Hermann
Probiotic/Synbiotic Treatment and Postoperative Complications in Colorectal Cancer Patients: Systematic Review and Meta-analysis of Randomized Controlled Trials
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Media type:
E-Article
Title:
Probiotic/Synbiotic Treatment and Postoperative Complications in Colorectal Cancer Patients: Systematic Review and Meta-analysis of Randomized Controlled Trials
Contributor:
Amitay, Efrat L.;
Carr, Prudence R.;
Gies, Anton;
Laetsch, Dana Clarissa;
Brenner, Hermann
Description:
<jats:p>Colorectal cancer (CRC) is a leading cause of morbidity and mortality. Post-CRC resection complications and lower quality of life (QoL) are associated with a lower long-term survival. Perioperative administration of probiotics/synbiotics might lower prevalence of side effects and improve QoL and survival among CRC patients. Medline, Web of Science, Cochrane database, Embase, and clinical trials registries were searched in January 2020. Altogether, 16 randomized placebo-controlled probiotic/synbiotic clinical trials that included patients undergoing CRC surgery and investigated postoperative complications and QoL side effects were found. Meta-analyses using random-effects model were performed on data from 11 studies to calculate the effects of probiotics/synbiotics on common CRC resection postoperative side effects and complications. Perioperative probiotics/synbiotics administration was associated with lower infection incidence (odds ratio [OR] = 0.34, <jats:italic toggle="yes">P</jats:italic> < 0.001), lower diarrheal incidence (OR = 0.38, <jats:italic toggle="yes">P</jats:italic> < 0.001), faster return to normal gut function (mean difference [MD] −0.66 days, <jats:italic toggle="yes">P</jats:italic> < 0.001), shorter postoperative antibiotics use (MD −0.64 days, <jats:italic toggle="yes">P</jats:italic> < 0.001), lower incidence of septicemia (OR = 0.31, <jats:italic toggle="yes">P</jats:italic> < 0.001), and shorter length of hospital stay (MD −0.41 days, <jats:italic toggle="yes">P</jats:italic> = 0.110). The results support the hypothesis that short-term perioperative administration of probiotics/synbiotics, which are easy to administer, have few side-effects, and are low cost compared with alternatives, might help to alleviate gastrointestinal symptoms and postoperative complications among CRC patients.</jats:p>