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Hudak, Mark L.; Flannery, Dustin D.; Barnette, Kimberly; Getzlaff, Trace; Gautam, Shiva; Dhudasia, Miren B.; Mukhopadhyay, Sagori; Pfeifer, Madeline R.; Ellington, Sascha R.; Galang, Romeo R.; Snead, Margaret C.; Woodworth, Kate R.; Zapata, Lauren B.; Puopolo, Karen M.; Hall, Richard Whit; Janssen, Dalton; Gomez, Enrique; McNew, Hailey; Steen, Christal; Cole, Evguenia; Graff, Brenda; Rao, Suma; Kathiravan, Suganya; Wade, Christina; [...]

Maternal and Newborn Hospital Outcomes of Perinatal SARS-CoV-2 Infection: A National Registry

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  • Media type: E-Article
  • Title: Maternal and Newborn Hospital Outcomes of Perinatal SARS-CoV-2 Infection: A National Registry
  • Contributor: Hudak, Mark L.; Flannery, Dustin D.; Barnette, Kimberly; Getzlaff, Trace; Gautam, Shiva; Dhudasia, Miren B.; Mukhopadhyay, Sagori; Pfeifer, Madeline R.; Ellington, Sascha R.; Galang, Romeo R.; Snead, Margaret C.; Woodworth, Kate R.; Zapata, Lauren B.; Puopolo, Karen M.; Hall, Richard Whit; Janssen, Dalton; Gomez, Enrique; McNew, Hailey; Steen, Christal; Cole, Evguenia; Graff, Brenda; Rao, Suma; Kathiravan, Suganya; Wade, Christina; [...]
  • Published: American Academy of Pediatrics (AAP), 2023
  • Published in: Pediatrics, 151 (2023) 2
  • Language: English
  • DOI: 10.1542/peds.2022-059595
  • ISSN: 1098-4275; 0031-4005
  • Origination:
  • Footnote:
  • Description: OBJECTIVES The American Academy of Pediatrics National Registry for the Surveillance and Epidemiology of Perinatal coronavirus disease 2019 (COVID-19) (NPC-19) was developed to provide information on the effects of perinatal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. METHODS National Registry for the Surveillance and Epidemiology of Perinatal COVID-19 participating centers entered maternal and newborn data for pregnant persons who tested positive for SARS-CoV-2 infection between 14 days before and 10 days after delivery. Incidence of and morbidities associated with maternal and newborn SARS-CoV-2 infection were assessed. RESULTS From April 6, 2020 to March 19, 2021, 242 centers in the United States centers reported data for 7524 pregnant persons; at the time of delivery, 78.1% of these persons were asymptomatic, 18.2% were symptomatic but not hospitalized specifically for COVID-19, 3.4% were hospitalized for COVID-19 treatment, and 18 (0.2%) died in the hospital of COVID-related complications. Among 7648 newborns, 6486 (84.8%) were tested for SARS-CoV-2, and 144 (2.2%) were positive; the highest rate of newborn infection was observed when mothers first tested positive in the immediate postpartum period (17 of 125, 13.6%). No newborn deaths were attributable to SARS-CoV-2 infection. Overall, 15.6% of newborns were preterm: among tested newborns, 30.1% of polymerase chain reaction-positive and 16.2% of polymerase chain reaction-negative were born preterm (P < .001). Need for mechanical ventilation did not differ by newborn SARS-CoV-2 test result, but those with positive tests were more likely to be admitted to a NICU. CONCLUSIONS Early in the pandemic, SARS-CoV-2 infection was acquired by newborns at variable rates and without apparent short-term effects. During a period that preceded widespread availability of vaccines, we observed higher than expected numbers of preterm births and maternal in-hospital deaths.
  • Access State: Open Access