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Media type:
E-Article
Title:
Immunomodulatory and antimicrobial effects of vitamin C
Contributor:
Mousavi, Soraya;
Bereswill, Stefan;
Heimesaat, Markus M.
imprint:
Akademiai Kiado Zrt., 2019
Published in:European Journal of Microbiology and Immunology
Language:
Not determined
DOI:
10.1556/1886.2019.00016
ISSN:
2062-8633
Origination:
Footnote:
Description:
<jats:p>Humans have lost their vitamin C-synthesizing capacities during evolution. Therefore, the uptake of this essential compound from external sources is mandatory in order to prevent vitamin C-deficient conditions resulting in severe morbidities such as scurvy. The potent antioxidant, immunomodulatory, and antiinfectious effects of vitamin C are known since the 1930s. We here (i) review the impact of vitamin C on innate and adaptive immune functions, (ii) provide an overview of its antimicrobial, antibacterial, antiviral, antiparasitic, and antifungal properties, and finally, (iii) discuss vitamin C as an adjunct treatment option for the combat of human infections by bacteria, particularly by emerging multidrug-resistant species.</jats:p>