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Media type:
E-Article
Title:
The relationship between proton pump inhibitors and renal disease
Contributor:
Morschel, Carine Franco;
Mafra, Denise;
Eduardo, José Carlos Carraro
imprint:
FapUNIFESP (SciELO), 2018
Published in:Brazilian Journal of Nephrology
Language:
Not determined
DOI:
10.1590/2175-8239-jbn-2018-0021
ISSN:
2175-8239;
0101-2800
Origination:
Footnote:
Description:
<jats:p>ABSTRACT Proton pump inhibitors (PPIs) bind to enzyme H+/K+-ATPase and inhibit its activity in the stomach, thus decreasing the secretion of gastric acid. PPIs may trigger acute interstitial nephritis, a potentially severe adverse event commonly associated with acute kidney injury. Studies have found that prolonged use of PPIs may increase the risk of chronic kidney disease (CKD). The increase in prescription and inadequate use of this class of medication calls for studies on the effects of prolonged PPI therapy on renal function. Therefore, this review aimed to analyze recent studies on the matter and discuss the possible consequences of the long-term use of PPIs on renal function.</jats:p>