Exercise in Patients on Dialysis: A Multicenter, Randomized Clinical Trial

Media type: E-Article
Title: Exercise in Patients on Dialysis: A Multicenter, Randomized Clinical Trial
Contributor: Manfredini, Fabio; Mallamaci, Francesca; D’Arrigo, Graziella; Baggetta, Rossella; Bolignano, Davide; Torino, Claudia; Lamberti, Nicola; Bertoli, Silvio; Ciurlino, Daniele; Rocca-Rey, Lisa; Barillà, Antonio; Battaglia, Yuri; Rapanà, Renato Mario; Zuccalà, Alessandro; Bonanno, Graziella; Fatuzzo, Pasquale; Rapisarda, Francesco; Rastelli, Stefania; Fabrizi, Fabrizio; Messa, Piergiorgio; De Paola, Luciano; Lombardi, Luigi; Cupisti, Adamasco; Fuiano, Giorgio; [...]
imprint: Ovid Technologies (Wolters Kluwer Health), 2017
Published in: Journal of the American Society of Nephrology
Language: English
DOI: 10.1681/asn.2016030378
ISSN: 1046-6673; 1533-3450
Origination:
Footnote:
Description: <jats:p>Previous studies have suggested the benefits of physical exercise for patients on dialysis. We conducted the Exercise Introduction to Enhance Performance in Dialysis trial, a 6-month randomized, multicenter trial to test whether a simple, personalized walking exercise program at home, managed by dialysis staff, improves functional status in adult patients on dialysis. The main study outcomes included change in physical performance at 6 months, assessed by the 6-minute walking test and the five times sit-to-stand test, and in quality of life, assessed by the Kidney Disease Quality of Life Short Form (KDQOL-SF) questionnaire. We randomized 296 patients to normal physical activity (control; <jats:italic toggle="yes">n</jats:italic>=145) or walking exercise (<jats:italic toggle="yes">n</jats:italic>=151); 227 patients (exercise <jats:italic toggle="yes">n</jats:italic>=104; control <jats:italic toggle="yes">n</jats:italic>=123) repeated the 6-month evaluations. The distance covered during the 6-minute walking test improved in the exercise group (mean distance±SD: baseline, 328±96 m; 6 months, 367±113 m) but not in the control group (baseline, 321±107 m; 6 months, 324±116 m; <jats:italic toggle="yes">P</jats:italic><0.001 between groups). Similarly, the five times sit-to-stand test time improved in the exercise group (mean time±SD: baseline, 20.5±6.0 seconds; 6 months, 18.2±5.7 seconds) but not in the control group (baseline, 20.9±5.8 seconds; 6 months, 20.2±6.4 seconds; <jats:italic toggle="yes">P</jats:italic>=0.001 between groups). The cognitive function score (<jats:italic toggle="yes">P</jats:italic>=0.04) and quality of social interaction score (<jats:italic toggle="yes">P</jats:italic>=0.01) in the kidney disease component of the KDQOL-SF improved significantly in the exercise arm compared with the control arm. Hence, a simple, personalized, home-based, low-intensity exercise program managed by dialysis staff may improve physical performance and quality of life in patients on dialysis.</jats:p>
Access State: Open Access

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