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Media type:
E-Article
Title:
Plasminogen activator inhibitor 1 (PAI-1) 1334G/A genetic polymorphism in colorectal cancer
Contributor:
Smolarz, Beata;
Romanowicz-Makowska, Hanna;
Kulig, Andrzej
Published:
Frontiers Media SA, 2003
Published in:
Acta Biochimica Polonica, 50 (2003) 2, Seite 489-495
Language:
Not determined
DOI:
10.18388/abp.2003_3701
ISSN:
1734-154X;
0001-527X
Origination:
Footnote:
Description:
Plasminogen activator inhibitor 1 (PAI-1) content in colorectal cancer tissue extracts may be of strong prognostic value: high levels of PAI-1 in tumours predict poor prognosis. The gene encoding PAI-1 is highly polymorphic and PAI-1 gene variability could contribute to the level of PAI-1 biosynthesis. In the present work the distribution of genotypes and frequency of alleles of the 1334G/A polymorphism in 92 subjects with colorectal cancer in samples of cancer tissue and distant mucosa samples as well as in blood were investigated. Blood samples age matched healthy individuals (n = 110) served as control. The 1334G/A polymorphism was determined by PCR amplification using allele specific primers. No differences in the genotype distributions and allele frequencies between blood, distant mucosa samples and cancer tissue were detected. However, the distribution of the genotypes of the 1334G/A polymorphism in patients differed significantly (P