Description:
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<jats:title>:</jats:title>
<jats:p>Mitochondrial disorders are clinically heterogeneous, resulting from nuclear gene and mitochondrial
mutations that disturb the mitochondrial functions and dynamics. There is a lack of evidence
linking mtDNA mutations to neurodegenerative disorders, mainly due to the absence of noticeable
neuropathological lesions in postmortem samples. This review describes various gene mutations
in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis,
and stroke. These abnormalities, including PINK1, Parkin, and SOD1 mutations, seem to reveal mitochondrial
dysfunctions due to either mtDNA mutation or deletion, the mechanism of which remains
unclear in depth.</jats:p>
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