Garland, Cedric F.;
Kim, June Jiwon;
Mohr, Sharif Burgette;
Gorham, Edward Doerr;
Grant, William B.;
Giovannucci, Edward L.;
Baggerly, Leo;
Hofflich, Heather;
Ramsdell, Joe Wesley;
Zeng, Kenneth;
Heaney, Robert P.
Meta-analysis of All-Cause Mortality According to Serum 25-Hydroxyvitamin D
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Media type:
E-Article
Title:
Meta-analysis of All-Cause Mortality According to Serum 25-Hydroxyvitamin D
Contributor:
Garland, Cedric F.;
Kim, June Jiwon;
Mohr, Sharif Burgette;
Gorham, Edward Doerr;
Grant, William B.;
Giovannucci, Edward L.;
Baggerly, Leo;
Hofflich, Heather;
Ramsdell, Joe Wesley;
Zeng, Kenneth;
Heaney, Robert P.
Published:
American Public Health Association, 2014
Published in:
American Journal of Public Health, 104 (2014) 8, Seite e43-e50
Language:
English
DOI:
10.2105/ajph.2014.302034
ISSN:
0090-0036;
1541-0048
Origination:
Footnote:
Description:
We examined the relationship between serum 25-hydroxyvitamin D (25[OH]D) and all-cause mortality. We searched biomedical databases for articles that assessed 2 or more categories of 25(OH)D from January 1, 1966, to January 15, 2013. We identified 32 studies and pooled the data. The hazard ratio for all-cause mortality comparing the lowest (0–9 nanograms per milliliter [ng/mL]) to the highest (> 30 ng/mL) category of 25(OH)D was 1.9 (95% confidence interval = 1.6, 2.2; P < .001). Serum 25(OH)D concentrations less than or equal to 30 ng/mL were associated with higher all-cause mortality than concentrations greater than 30 ng/mL (P < .01). Our findings agree with a National Academy of Sciences report, except the cutoff point for all-cause mortality reduction in this analysis was greater than 30 ng/mL rather than greater than 20 ng/mL.