Zhdanov, K. V.;
Semenov, A. V.;
Karyakin, S. S.;
Kozlov, K. V.;
Sukachev, V. S.;
Ostankova, Yu. V.;
Valutite, D. E.;
Zueva, E. B.;
Sidorov, R. S.;
Saulevich, A. V.;
Bulan’kov, Yu. I.;
Lyashenko, Yu. I.;
Ivanov, K. S.
s MadCAM-1 as an immunological marker in the «gut liver axis» at patients with chronic hepatitis C and excess body weight
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Media type:
E-Article
Title:
s MadCAM-1 as an immunological marker in the «gut liver axis» at patients with chronic hepatitis C and excess body weight
Contributor:
Zhdanov, K. V.;
Semenov, A. V.;
Karyakin, S. S.;
Kozlov, K. V.;
Sukachev, V. S.;
Ostankova, Yu. V.;
Valutite, D. E.;
Zueva, E. B.;
Sidorov, R. S.;
Saulevich, A. V.;
Bulan’kov, Yu. I.;
Lyashenko, Yu. I.;
Ivanov, K. S.
Description:
<jats:p><jats:bold><jats:underline>Background and aims</jats:underline></jats:bold><jats:underline>: to estimate concentration of sMadCAM-1 in peripheral blood at patients with chronic hepatitis C with excess body weight.</jats:underline></jats:p><jats:p><jats:bold><jats:underline>Materials and methods</jats:underline></jats:bold><jats:underline>: The research included 88 patients (67 men, 21 women 41.4±3.2 years of age) with chronic hepatitis C (CHC) and excess body weight (the index of body mass is</jats:underline>³<jats:underline>25 kg/m2, and abdominal circumference more than 94 cm in men, and 80 cm in women) with various morfofunktsionalny changes in a liver and a small bowel. From them men there were 67 people, women – 21, middle age was 41.4±3.2 years.</jats:underline></jats:p><jats:p><jats:underline>To all the patients complex clinical, biochemical, virologic, morphological trial was carried out. The functional condition of intestines was estimated by identification of a small intestinal bacterial overgrowth (SIBO) when carrying out the hydrogen respiratory test (HRT) with lactulose and existence of endoscopic signs of inflammation of a mucous membrane of intestines at a fibroezofagogastroduodenoskopiya. The quantitative assessment of a mucosal addressin cell adhesion molecule -1 was carried out by the definition concentration of its soluble form (sMadCAM-1) in a blood plasma by enzyme immunoassay method.</jats:underline></jats:p><jats:p><jats:bold><jats:underline>Results</jats:underline></jats:bold><jats:underline>: the sMadCAM-1 level of peripheral blood at the patients with excess body weight increased in process of progressing of a stage of chronic hepatitis C (F0 – 349.10 (324.27-373.92) ng/ml; F1/2 – 439.69 (406.43-472.94) ng/ml; F3/4 – 1057.82 (593.38-1522.26) ng/ml; p</jats:underline>˂<jats:underline>0.05), existence of a syndrome of excess bacterial growth and endoscopic signsof a duodenitis. Besides, patients had its concentration more with the biochemical signs characterizing cytolytic (at ALT</jats:underline>˃<jats:underline>N: 502.54 (432.04-573.03) ng/ml against 381.04(345.49-416.58) at the ALT normal values), cholestatic (at GGTP</jats:underline>˃<jats:underline>N: 550.59 (453.31-647.88) ng/ml against 400.86(365.13-436.59) atnormal GGTP, p values 0.05; at ALP N: 572.2 (353.7-790.8) ng/ml against 468.7 (408.5-528.9) ng/ml at normal ALP, p values 0.05) and metabolic syndromes (at glucose of blood, TG, VLDL N: 562.93 (369.59-756.27) ng/ml, 681.15 (387.81-974.49) ng/ml, 809.65(124.04-1495.28) against (438.34(391.36-485.31) ng/ml), (421.69(379.41-463.97) ng/ml), 434.47(389.45-479.48), p values 0.05 at normal values of these indicators respectively).</jats:underline></jats:p><jats:p><jats:bold><jats:underline>Conclusion</jats:underline></jats:bold><jats:underline>: Progressing of fibrosis and functional disturbances in intestines are interconnected with increase in concentration of MadCAM-1 in blood that allows to consider pathological changes in intestines of various genesis as the accessory factor promoting progressing of С</jats:underline><jats:underline>HC at patients with excess body weight. Besides, definition of concentration of sMadCAM-1 in peripheral blood can be used as one of markers of noninvasive diagnostics of a stage of fibrosis at the patients with С</jats:underline><jats:underline>HC and excess body weight.</jats:underline></jats:p>