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Costanzo, Antonio; Russo, Filomena; Galluzzo, Marco; Stingeni, Luca; Scuderi, Roberta; Zichichi, Leonardo; Papini, Manuela; Di Costanzo, Luisa; Conti, Andrea; Burlando, Martina; Chiricozzi, Andrea; Gaiani, Francesca Maria; Mugheddu, Cristina; Musumeci, Maria Letizia; Gisondi, Paolo; Piaserico, Stefano; Dapavo, Paolo; Venturini, Marina; Pagnanelli, Gianluca; Amerio, Paolo; Potenza, Concetta; Peris, Ketty; Cantoresi, Franca; Trevisini, Sara; [...]

Secukinumab Exhibits Sustained and Stable Response in Patients with Moderate-to-Severe Psoriasis: Results from the SUPREME Study

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  • Media type: E-Article
  • Title: Secukinumab Exhibits Sustained and Stable Response in Patients with Moderate-to-Severe Psoriasis: Results from the SUPREME Study
  • Contributor: Costanzo, Antonio; Russo, Filomena; Galluzzo, Marco; Stingeni, Luca; Scuderi, Roberta; Zichichi, Leonardo; Papini, Manuela; Di Costanzo, Luisa; Conti, Andrea; Burlando, Martina; Chiricozzi, Andrea; Gaiani, Francesca Maria; Mugheddu, Cristina; Musumeci, Maria Letizia; Gisondi, Paolo; Piaserico, Stefano; Dapavo, Paolo; Venturini, Marina; Pagnanelli, Gianluca; Amerio, Paolo; Potenza, Concetta; Peris, Ketty; Cantoresi, Franca; Trevisini, Sara; [...]
  • Published: Medical Journals Sweden AB, 2021
  • Published in: Acta Dermato-Venereologica, 101 (2021) 10, Seite adv00576
  • Language: Not determined
  • DOI: 10.2340/00015555-3816
  • ISSN: 1651-2057; 0001-5555
  • Keywords: Dermatology ; General Medicine
  • Origination:
  • University thesis:
  • Footnote:
  • Description: <jats:p>Secukinumab, a fully human monoclonal antibody, neutralizes interleukin-17A, a cornerstone cytokine driving the multiple manifestations of psoriasis. This post-hoc analysis of the SUPREME study was performed to determine the sustainability of response to secukinumab in terms of Psoriasis Area and Severity Index (PASI) 90 in patients with moderate-to-severe plaque psoriasis. Based on PASI 90 response at week 16, patients were stratified as PASI 90 responders (PASI90R, n = 337) or non-responders (PASI90NR, n = 72). At week 20, 94.2% (n = 295/313) achieved PASI 90/100 response in PASI90R, with response maintained through week 48 (89.6%, n = 189/211). An increased proportion of patients achieved PASI 90/100 response in PASI90NR (week 20: 29.9%, n = 20/67; week 48: 57.1%, n = 20/35). Overall, 64.4% patients achieved absolute PASI score = 0 at week 24 with response sustained to week 48 (66.9%). Secukinumab showed sustained and stable efficacy in maintaining PASI 90 response in patients with moderate-to-severe plaque psoriasis up to week 48.</jats:p>
  • Access State: Open Access