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Aleppo, Grazia; Beck, Roy W.; Bailey, Ryan; Ruedy, Katrina J.; Calhoun, Peter; Peters, Anne L.; Pop-Busui, Rodica; Philis-Tsimikas, Athena; Bao, Shichun; Umpierrez, Guillermo; Davis, Georgia; Kruger, Davida; Bhargava, Anuj; Young, Laura; Buse, John B.; McGill, Janet B.; Martens, Thomas; Nguyen, Quang T.; Orozco, Ian; Biggs, William; Lucas, K. Jean; Polonsky, William H.; Price, David; Bergenstal, Richard M.; [...]

The Effect of Discontinuing Continuous Glucose Monitoring in Adults With Type 2 Diabetes Treated With Basal Insulin

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  • Media type: E-Article
  • Title: The Effect of Discontinuing Continuous Glucose Monitoring in Adults With Type 2 Diabetes Treated With Basal Insulin
  • Contributor: Aleppo, Grazia; Beck, Roy W.; Bailey, Ryan; Ruedy, Katrina J.; Calhoun, Peter; Peters, Anne L.; Pop-Busui, Rodica; Philis-Tsimikas, Athena; Bao, Shichun; Umpierrez, Guillermo; Davis, Georgia; Kruger, Davida; Bhargava, Anuj; Young, Laura; Buse, John B.; McGill, Janet B.; Martens, Thomas; Nguyen, Quang T.; Orozco, Ian; Biggs, William; Lucas, K. Jean; Polonsky, William H.; Price, David; Bergenstal, Richard M.; [...]
  • Published: American Diabetes Association, 2021
  • Published in: Diabetes Care, 44 (2021) 12, Seite 2729-2737
  • Language: English
  • DOI: 10.2337/dc21-1304
  • ISSN: 0149-5992; 1935-5548
  • Origination:
  • Footnote:
  • Description: OBJECTIVE To explore the effect of discontinuing continuous glucose monitoring (CGM) after 8 months of CGM use in adults with type 2 diabetes treated with basal without bolus insulin. RESEARCH DESIGN AND METHODS This multicenter trial had an initial randomization to either real-time CGM or blood glucose monitoring (BGM) for 8 months followed by 6 months in which the BGM group continued to use BGM (n = 57) and the CGM group was randomly reassigned either to continue CGM (n = 53) or discontinue CGM with resumption of BGM for glucose monitoring (n = 53). RESULTS In the group that discontinued CGM, mean time in range (TIR) 70–180 mg/dL, which improved from 38% before initiating CGM to 62% after 8 months of CGM, decreased after discontinuing CGM to 50% at 14 months (mean change from 8 to 14 months −12% [95% CI −21% to −3%], P = 0.01). In the group that continued CGM use, little change was found in TIR from 8 to 14 months (baseline 44%, 8 months 56%, 14 months 57%, mean change from 8 to 14 months 1% [95% CI −11% to 12%], P = 0.89). Comparing the two groups at 14 months, the adjusted treatment group difference in mean TIR was −6% (95% CI −16% to 4%, P = 0.20). CONCLUSIONS In adults with type 2 diabetes treated with basal insulin who had been using real-time CGM for 8 months, discontinuing CGM resulted in a loss of about one-half of the initial gain in TIR that had been achieved during CGM use.
  • Access State: Open Access