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Media type:
E-Article
Title:
Resistance training alone or combined with leucine supplementation improves the serum lipid profile of diabetic rats, whereas leucine alone does not
Contributor:
Martins, Carlos Eduardo C.;
de Sousa Lima, Vanessa B.;
Ribeiro, Henrique Quintas T.;
Tirapegui, Julio
Description:
<jats:title>Abstract</jats:title>
<jats:p>
<jats:bold>Objectives.</jats:bold> Diabetes mellitus is associated with dyslipidemia, which contributes to a higher risk of thrombosis, atherosclerosis and cardiovascular disease. This study evaluated the effects of leucine and resistance training on the serum lipid profile in rats with streptozotocin-induced diabetes for 8 weeks.</jats:p>
<jats:p>
<jats:bold>Methods.</jats:bold> Wistar rats with neonatal streptozotocin-induced diabetes were treated with leucine supplementation (5%) and/or resistance training (3 days per week) for 8 weeks, and divided in DL (diabetic and leucine), DT (diabetic and resistance training group) and DLT (diabetic, leucine and resistance training) groups. Others 2 groups of animals received isonitrogen AIN-93M diet that was defined as a control diet: group D (diabetic untreated) and group C (non-diabetic).</jats:p>
<jats:p>
<jats:bold>Results.</jats:bold> The decrease in serum total cholesterol and increase in high-density lipoprotein cholesterol (HDL-C) was observed in the resistance training-induced diabetic rats when compared with diabetic rats. There was no change in serum lipid profile in leucine-supplemented diabetic rats and no synergistic effect of leucine and resistance training. The fasting glucose levels were reduced in all animals treated compared to D group.</jats:p>
<jats:p>
<jats:bold>Conclusion.</jats:bold> The diabetic trained rats demonstrate a protective effect of resistance training on the serum lipid profile.</jats:p>