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Banhart, Sebastian; Jansen, Klaus; Buder, Susanne; Tamminga, Thalea; Calvignac-Spencer, Sébastien; Pilz, Tanja; Martini, Andrea; Dudareva, Sandra; Nikisins, Sergejs; Dehmel, Kerstin; Zuelsdorf, Gabriele; Guhl, Eva; Graeber, Ingeborg; Kohl, Peter K; Unemo, Magnus; Bremer, Viviane; Heuer, Dagmar

Molecular epidemiological typing of Neisseria gonorrhoeae isolates identifies a novel association between genogroup G10557 (G7072) and decreased susceptibility to cefixime, Germany, 2014 to 2017

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  • Media type: E-Article
  • Title: Molecular epidemiological typing of Neisseria gonorrhoeae isolates identifies a novel association between genogroup G10557 (G7072) and decreased susceptibility to cefixime, Germany, 2014 to 2017
  • Contributor: Banhart, Sebastian; Jansen, Klaus; Buder, Susanne; Tamminga, Thalea; Calvignac-Spencer, Sébastien; Pilz, Tanja; Martini, Andrea; Dudareva, Sandra; Nikisins, Sergejs; Dehmel, Kerstin; Zuelsdorf, Gabriele; Guhl, Eva; Graeber, Ingeborg; Kohl, Peter K; Unemo, Magnus; Bremer, Viviane; Heuer, Dagmar
  • imprint: European Centre for Disease Control and Prevention (ECDC), 2020
  • Published in: Eurosurveillance
  • Language: English
  • DOI: 10.2807/1560-7917.es.2020.25.41.1900648
  • ISSN: 1560-7917
  • Keywords: Virology ; Public Health, Environmental and Occupational Health ; Epidemiology
  • Origination:
  • Footnote:
  • Description: <jats:sec> <jats:title>Background</jats:title> <jats:p>Emerging antimicrobial resistance (AMR) challenges gonorrhoea treatment and requires surveillance.</jats:p> </jats:sec> <jats:sec> <jats:title>Aim</jats:title> <jats:p>This observational study describes the genetic diversity of <jats:italic>Neisseria gonorrhoeae</jats:italic> isolates in Germany from 2014 to 2017 and identifies <jats:italic>N. gonorrhoeae</jats:italic> multi-antigen sequence typing (NG-MAST) genogroups associated with AMR or some patient demographics.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>1,220 gonococcal isolates underwent AMR testing and NG-MAST. Associations between genogroups and AMR or sex/age of patients were statistically assessed.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Patients’ median age was 32 years (interquartile range: 25–44); 1,078 isolates (88.4%) originated from men. In total, 432 NG-MAST sequence types including 156 novel ones were identified, resulting in 17 major genogroups covering 59.1% (721/1,220) of all isolates. Genogroups G1407 and G10557 (G7072) were significantly associated with decreased susceptibility to cefixime (Kruskal–Wallis chi-squared: 549.3442, df: 16, p &lt; 0.001). Their prevalences appeared to decline during the study period from 14.2% (15/106) to 6.2% (30/481) and from 6.6% (7/106) to 3.1% (15/481) respectively. Meanwhile, several cefixime susceptible genogroups’ prevalence seemed to increase. Proportions of isolates from men differed among genogroups (Fisher’s exact test, p &lt; 0.001), being e.g. lower for G25 (G51) and G387, and higher for G5441 and G2992. Some genogroups differed relative to each other in affected patients’ median age (Kruskal–Wallis chi-squared:  47.5358, df:  16, p &lt; 0.001), with e.g. G25 (G51) and G387 more frequent among ≤ 30 year olds and G359 and G17420 among ≥ 40 year olds.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>AMR monitoring with molecular typing is important. Dual therapy (ceftriaxone plus azithromycin) recommended in 2014 in Germany, or only the ceftriaxone dose of this therapy, might have contributed to cefixime-resistant genogroups decreasing.</jats:p> </jats:sec>
  • Access State: Open Access