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Nielsen, Karen Leth; Sørensen, Marc; Hertz, Frederik Boëtius; Misiakou, Maria Anna; Hasman, Henrik; Häussler, Susanne; Helleberg, Marie; Schønning, Kristian

Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021

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  • Media type: E-Article
  • Title: Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021
  • Contributor: Nielsen, Karen Leth; Sørensen, Marc; Hertz, Frederik Boëtius; Misiakou, Maria Anna; Hasman, Henrik; Häussler, Susanne; Helleberg, Marie; Schønning, Kristian
  • Published: European Centre for Disease Control and Prevention (ECDC), 2023
  • Published in: Eurosurveillance, 28 (2023) 17
  • Language: English
  • DOI: 10.2807/1560-7917.es.2023.28.17.2300196
  • ISSN: 1560-7917
  • Keywords: Virology ; Public Health, Environmental and Occupational Health ; Epidemiology
  • Origination:
  • Footnote:
  • Description: A hypervirulent Klebsiella pneumoniae SL218 (ST23-KL57), phylogenetically distinct from the classical hypervirulent SL23 (ST23-KL1) lineage, was transmitted between hospitalised patients in Denmark in 2021. The isolate carried a hybrid resistance and virulence plasmid containing bla NDM-1 and a plasmid containing bla OXA-48 (pOXA-48); the latter plasmid was horizontally transferred within-patient to Serratia marcescens. The convergence of drug resistance and virulence factors in single plasmids and in different lineages of K. pneumoniae is concerning and requires surveillance.
  • Access State: Open Access