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Media type:
E-Article
Title:
TUBERCULOUS PATIENTS; : CROSS SECTIONAL STUDY OF BCG VACCINATION AND ANTIBODY TITRE IN HOUSE HOLD CONTACTS OF TUBERCULOUS PATIENTS
:
CROSS SECTIONAL STUDY OF BCG VACCINATION AND ANTIBODY TITRE IN HOUSE HOLD CONTACTS OF TUBERCULOUS PATIENTS
Published in:
The Professional Medical Journal, 20 (2013) 5, Seite 678-683
Language:
Not determined
DOI:
10.29309/tpmj/2013.20.05.1430
ISSN:
2071-7733;
1024-8919
Origination:
Footnote:
Description:
Objective: This study was designed to analyze the BCG vaccination status and compare the immune globulins levels in thehousehold contacts of tuberculous patients with non contacts of unexposed healthy peoples. Place: Gulab Devi Hospital, Post GraduateMedical Institute and Defense Housing Authority Lahore. Study design: Cross sectional study. Materials and Methods: Investigationslike ESR were done and the sera of 200 persons included in the study were tested for anti tuberculous antibodies by ELISA. BCGvaccination present or absent and scars were positive or negative in both groups were included. Results: The combined serologicalpositivity of the household contacts was 65.8% and for non-contacts was 34.1%. BCG scars were mostly absent in the householdcontacts as well as in non-contacts; But statistically IgG and IgA were present significantly by higher number in the household contacts ascompared to non-contacts, where as no significant difference in the IgM levels. These immunoglobulins status were compared with BCGscars in both study and control groups. The results were analyzed by SPSS version 14. Conclusions: Household contacts of tuberculosispatients are more susceptible to tuberculosis as compared to the non-contacts, as shown by positive and negative status ofantituberculous antibodies in the house hold contacts. More over BCG vaccination has no significant role in humoral evaluation.