Fernández-Herrera, María A.;
Sandoval-Ramírez, Jesús;
Meza-Reyes, Socorro;
Montiel-Smith, Sara
Side-chain opening of steroidal sapogenins to form 22-oxocholestanic skeletons. An approach to analogues of the aglycone of the potent anticancer agent OSW-1
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Media type:
E-Article
Title:
Side-chain opening of steroidal sapogenins to form 22-oxocholestanic skeletons. An approach to analogues of the aglycone of the potent anticancer agent OSW-1
Contributor:
Fernández-Herrera, María A.;
Sandoval-Ramírez, Jesús;
Meza-Reyes, Socorro;
Montiel-Smith, Sara
imprint:
Sociedad Quimica de Mexico, A.C., 2019
Published in:Journal of the Mexican Chemical Society
Language:
Not determined
DOI:
10.29356/jmcs.v53i3.993
ISSN:
2594-0317;
1870-249X
Origination:
Footnote:
Description:
<jats:p>The side-chain opening of 25R and 25S steroidal sapogenins to form 22-oxocholestanic skeletons is described. The transformation was produced under mild conditions providing high yields (70-87%), in a one pot procedure (some acetylated starting material is recovered). This methodology yields 17-deoxy-26-oxy analogues of the aglycone of the potent anticancer agent OSW-1. All products were fully characterized by 1D and 2D NMR; the most representative displacements are briefly discussed.

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