> Details

Douglas, Andrea F.; Weiner, Howard L.; Schwartz, David R.

Prolonged intrathecal baclofen withdrawal syndrome : Case report and discussion of current therapeutic management

Reference
management

Bookmarks

Remove from
bookmarks

Share this on Whatsapp

Close

Bookmarks



You can manage bookmarks using lists, please log in to your user account for this.
  • Media type: E-Article
  • Title: Prolonged intrathecal baclofen withdrawal syndrome : Case report and discussion of current therapeutic management : Case report and discussion of current therapeutic management
  • Contributor: Douglas, Andrea F.; Weiner, Howard L.; Schwartz, David R.
  • Published: Journal of Neurosurgery Publishing Group (JNSPG), 2005
  • Published in: Journal of Neurosurgery, 102 (2005) 6, Seite 1133-1136
  • Language: Not determined
  • DOI: 10.3171/jns.2005.102.6.1133
  • ISSN: 0022-3085
  • Origination:
  • Footnote:
  • Description: ✓ The authors describe a patient who experienced a prolonged course of intrathecal baclofen withdrawal syndrome after removal of an implantable baclofen pump for treatment of pump infection and meningitis. The current literature outlines management options for the acute management of this syndrome. In this report the authors discuss the long-term presentation of this syndrome and suggest a treatment strategy for management of the syndrome.A 37-year-old man who presented with a baclofen pump infection and meningitis experienced acute onset of intrathecal baclofen withdrawal syndrome 12 hours after the pump had been surgically removed. The patient's symptoms evolved into a severe, treatment-refractory withdrawal syndrome lasting longer than 1 month.Oral baclofen replacement with adjunctive administration of parenteral γ-aminobutyric acid agonists only served to stabilize the patient's critical condition throughout his hospital course. Replacement of the baclofen pump and restoration of intrathecal delivery of the medication was necessary to trigger the patient's dramatic recovery and complete reversal of the withdrawal syndrome within approximately 48 hours.These findings indicate that a more direct method of treating infected baclofen pumps than immediate surgical removal is necessary to prevent the onset of intrathecal baclofen withdrawal syndrome. Various options for preventing the onset of the syndrome while simultaneously treating the infection are discussed.