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Baumbach, Andreas; Cui, Yu-Xin; Evans, Rebecca N.; Culliford, Lucy; Johnson, Tom; Rogers, Chris A.; Reeves, Barnaby C.; Bucciarelli-Ducci, Chiara; Harris, Jessica; Hamilton, Mark; Madeddu, Paolo

A cohort study of circulating progenitor cells after ST-segment elevation and non-ST segment elevation myocardial infarction in non-diabetic and diabetic patients

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  • Media type: E-Article
  • Title: A cohort study of circulating progenitor cells after ST-segment elevation and non-ST segment elevation myocardial infarction in non-diabetic and diabetic patients
  • Contributor: Baumbach, Andreas; Cui, Yu-Xin; Evans, Rebecca N.; Culliford, Lucy; Johnson, Tom; Rogers, Chris A.; Reeves, Barnaby C.; Bucciarelli-Ducci, Chiara; Harris, Jessica; Hamilton, Mark; Madeddu, Paolo
  • imprint: Frontiers Media SA, 2022
  • Published in: Frontiers in Cardiovascular Medicine
  • Language: Not determined
  • DOI: 10.3389/fcvm.2022.1011140
  • ISSN: 2297-055X
  • Keywords: Cardiology and Cardiovascular Medicine
  • Origination:
  • Footnote:
  • Description: <jats:sec><jats:title>Background</jats:title><jats:p>Myocardial infarction induces elevation of progenitor cells in the circulation, a reparative response inhibited by type-2 diabetes.</jats:p></jats:sec><jats:sec><jats:title>Objectives</jats:title><jats:p>Determine if myocardial infarct severity and diabetes interactively influence the migratory activity of CD34+/CXCR4+ progenitor cells and if the migratory test predicts cardiac outcomes.</jats:p></jats:sec><jats:sec><jats:title>Materials and methods</jats:title><jats:p>A longitudinal study was conducted on patients with or without diabetes with a STEMI or NSTEMI. CD34+/CXCR4+ cells were measured in the peripheral blood using flow cytometry, and migratory activity was tested <jats:italic>in vitro</jats:italic> on cells isolated from samples collected on days 0 and 4 post-infarct. Cardiac function was assessed at three months using cardiac MRI.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of 1,149 patients screened, 71 (6.3%) were eligible and consented. Fifty had STEMI (16 with diabetes) and 21 NSTEMI (8 with diabetes). The proportion of CD34+/CXCR4+ cells within blood mononuclear cells was 1.96 times higher after STEMI compared with NSTEMI (GMR = 1.96, 95% CI 0.87, 4.37) and 1.55 times higher in patients with diabetes compared to patients without diabetes (GMR = 1.55, 95% CI 0.77, 3.13). In the latter, STEMI was associated with a 2.42-times higher proportion of migrated CD34 + /CXCR4 + cells compared with NSTEMI (GMR = 2.42, 95% CI 0.66, 8.81). In patients with diabetes, the association was the opposite, with a 55% reduction in the proportion of migrated CD34+/CXCR4+ cells. No statistically significant associations were observed between the frequency in peripheral blood or <jats:italic>in vitro</jats:italic> migration capacity of CD34+/CXCR4+ cells and MRI outcomes.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>We document the interaction between infarct and diabetes on the migratory activity of CD34+/CXCR4+ cells. The test did not predict functional outcomes in the studied cohort.</jats:p></jats:sec>
  • Access State: Open Access